The broader NSE Nifty closed down by 16 points to end at 10,410.90 following weakness in Asia and US markets.
Despite gains in banking, media and IT sectors, the broader market remained weak with losses in metal, energy, FMCG and infra.
On the global front, Asian markets ended lower following the sacking of US Secretary of State Rex Tillerson amid talk of potential US tariffs against China. Nikkei, Hang Seng, Shanghai, ASX 200 and Kospi were down 0.3-0.9 per cent.
European markets recouped opening losses trading mildly higher.
The Nifty 50 declined 15.95 points or 0.15 percent to end at 10,410.90, its lowest closing level since 9 March 2018, before moving in a range of 10,420.35 and 10,336.30.
It saw an intra-day movement of about 84.05 points.
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Sector-wise, energy fell 0.65 per cent, realty 0.51 per cent, metal 0.57 per cent, fmcg 0.42 per cent, infra 0.25 per cent and auto 0.03 percent, while PSU Bank fell by 1.75, bank 0.46 per cent, IT 0.41 per cent, private bank 0.40 per cent, finance services 0.03 per cent.
Major Index gainers were TechM, AmbujaCement, Bajaj Finance, Yes Bank, UltraCemCo, Sbin and Axis Bank.
Among the Index lossers were IOC, InfraTel, HindPetro, HeroMotoCo, ONGC, Tata Steel, BhartiAirtel and Bosch Ltd.
The market breadth, indicating its overall health, remained negative, a total of 868 scrips advanced and 896 declined, while 76 remained unchanged.
As many as 191 securities hit their price bands.
Turnover in the cash segment fell to Rs 27,629.63 crore, from Rs 44,691.56 crore as on Tuesday.
A total of 15,813.61 lakhs shares changed hands in 92,05,792 trades. The market capitalisation of listed firms on the NSE stood at Rs 1,43,15,218.98 crore.