The broader Nifty slipped by 40.50 points to close at 10,114.75 dragged by profit booking in PSU banks, media, realty, IT, infra and auto sectors amid volatility around the expiry of monthly derivative contracts.
A sharp rise in crude oil prices yesterday also dented investors' sentiments.
Overseas, European stocks were trading lower as traders reacted to a rate hike from the US Federal Reserve. France CAC and Germany DAX were down 1 percent each while Britain FTSE declined 0.6 percent.
Asian markets closed mixed. Japan's Nikkei 225 rose 0.99 percent while China's Shanghai Composite, Hong Kong's Hang Seng and Australia's ASX 200 fell 0.2-1 percent.
Back home, the Nifty fell by 40.50 points or 0.40 per cent to end at 10,114.75 after hovering in a range of 10,207.85 and 10,105.40. It witnessed an intra-day movement of about 102.45 points.
Sector-wise, PSU Bank fell by 2.01 per cent, Media 1.29 per cent, Realty 1.21 per cent, Infra 0.82 per cent, IT 0.95 percent, Auto 0.89 percent, Pharma 0.60 percent, Finance service 0.58 percent, Bank 0.47 percent, Private Bank 0.42 per cent and FMCG 0.22 percent.
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On the other hand, Metal and Energy rose by 0.32 per cent and 0.36 percent.
Major index gainers were ONGC, Vedl, Reliance, Indus- IndBank, Tata Motors, Sunpharma, GAIL and Hindalco.
The losers were Bpcl, HindPetro, SBIN, Wipro, ICICI Bank, Maruti, M&M, Cipla, UltraCemCo and Bosch Ltd.
The market breadth, indicating its overall health, remained negative as a total of 425 scrips advanced and 1,391 declined, while 57 remained unchanged. Total securities that have hit their price bands today were 218.
The cash segment turnover ease to Rs 27,478.66 crore from Rs 28,410.65 crore as on Wednesday.
A total of 14,510.75 lakh shares changed hands in 99,19,562 trades. The market capitalisation of listed firms on the NSE stood at Rs 1,39,07,873.55 crore.