However, shares of IT and banking sectors firmed up.
The NSE 50-share Nifty index touched an intra-day high of 8,820.45 but could not sustain at that level and ended down by 12.75 points at 8,792.30.
The broader Nifty slipped below the key 8,800-level.
Overseas, European stocks and Asian stocks suffered modest losses amid caution ahead of US Federal Reserve Chairwoman Janet Yellen's upcoming congressional testimony.
The NSE 50-share Nifty index opened higher at 8,819.90 and hovered between 8,820.45 and 8,772.45 before closing at 8,792.30, a marginal fall of 12.75 points, or 0.14 per cent.
More From This Section
Meanwhile, Foreign portfolio investors bought shares worth net Rs 306.74 crore yesterday, as per provisional data.
On the sectoral front, auto fell by 1.53 per cent, media 0.93 per cent, metal 0.90 per cent, pharma 0.78 per cent and realty 0.72 per cent.
However, IT rose by 0.20 per cent, banking 0.03 per cent and PVT Bank 0.02 per cent.
Major index losers were Tata Motors 4.60 per cent, BPCL 3.15 per cent, Zee Ltd 2.16 per cent and Hero Motors 1.97 per cent.
However, Bharti Artl rose by 3.04 per cent, followed by Gail 2.84 per cent, Idea 2.47 per cent, Reliance 1.94 per cent and Eicher Motors 1.84 per cent.
Turnover in the cash segment rose to Rs 19,942.50 crs from Rs 19,892.71 crore yesterday.
A total of 10,838.07 lakh shares changed hands in 80,44,925 trades. The market capitalisation of NSE stood at Rs 11,397,710 crore.