The market sentiment was dented by weak global cues after the Chinese manufacturing dropped to seven-month low in February, according to a HSBC/Markit survey.
Also, the indication from minutes of US Fed Reserve's January meet that the central bank would keep reducing its bond buying programme, renewed the liquidity concerns.
Meanwhile, foreign institutional investors bought shares worth Rs 468.47 crore yesterday, as per provisional data from stock exchanges.
However, drugmaker Dr Reddy's Lab witnessed buying interest and gained 1.78 per cent.
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The 50-share Nifty hovered between a high of 6,129.10 and a low of 6,086.45, before closing at 6,091.45, showing a fall of 61.30 points, or 1 per cent, over its previous close.
Other losers included Grasim, IndusInd Bank, ACC, IDFC and Ambuja Cement. JP Associate, Bajaj Auto and Tata Power were some of the gainers.