The Super Eagles have taken just two points from six matches in their last two appearances at the World Cup, but have higher hopes this time around after winning the African Nations' Cup last year.
"I think their coach is their biggest weapon, because he's well experienced, he knows the game well," Keshi told FIFA.Com
"For the Iran game we have to be focused. We have to concentrate and do our job. We're not going to take Iran lightly because they're not going to take us lightly, so we have to go out with everything that we have.
Nigeria's campaign will be spearheaded by Chelsea's John Obi Mikel and goalkeeper Vincent Enyeama, whilst captain Joseph Yobo could make his 100th appearance for his country against Argentina in the final group game.
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And Keshi is relying on them to guide his young squad.
"You can't buy this sort of experience. I pray that Enyeama, Yobo and Mikel Obi will bring all their experience. Youth is good, but if we can combine youth and experience that will be great for us."