After top seeds Novak Djokovic and Roger Federer were disposed of in the semi-finals, the championship match will be the first not to feature either Djokovic, Federer or Rafael Nadal since the 2005 Australian Open.
No wonder Nishikori is still pinching himself after knocking out Wimbledon champion and seven-time Grand Slam winner Djokovic in the semi-finals.
"I am a little bit surprised for me to play the final," said the 24-year-old, whose previous best Grand Slam run had been a quarter-final at the 2012 Australian Open.
His success comes despite his having to sit out the Toronto and Cincinnati Masters on the eve of the US Open to have a cyst removed from his toe, a painful problem which almost forced him to skip New York.
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"I just started playing points a few days ago before the tournament. I didn't even know if I should come to New York, so I wasn't expecting anything actually," said the 10th seed.
"Obviously with Li Na having as much success as she's had the past few years and Kei's done very well," said Chang.
"This year's really been a breakthrough year for him and I wouldn't be surprised if that really propels a lot of Asian tennis, particularly on the men's side because women have really been doing well.
"It's going to give them a lot of confidence to go out and play. A great example is what Venus and Serena have done for young American women.