Clooney, 54, who married Lebanese-British lawyer Amal Alamuddin, 37, last year, said older actors should accept that they would be offered characters suiting their age, reported Female First.
"I think for all of us, you have to come to terms with getting older and not trying to fight it. You have a couple of options - which is get older or die.
"And so you have to get used to that idea that your roles in films and who you are and how you are perceived is going to change. That will disappoint people at times."
"I'm a big believer in the idea that you cannot try to look younger. You just have to look the best you can at the age you are.