The 37-year-old addressed the rumours of squabbles on 'The Late Show With David Letterman', reported Contactmusic.
"We all get along very well. I don't know why everybody says that we are fighting," Longoria said.
Earlier reports suggested that Teri Hatcher's (Susan Mayer), name was left off the notes attached to the farewell presents, given by the cast to their colleagues.
Speaking to the presenter about the final days filming for the show, Longoria said the cast gave the crew luggage as a parting gift.
However she failed to acknowledge that Hatcher's name had been deliberately left off the card.
"We gave the crew carry-on luggage that said, 'Take us with you in all of your journeys'. There is no competition between us. It's acting! It's not football."