Four American citizens, including Ambassador Christopher Stevens, were killed in the double raid targeting the US mission and nearby CIA annex on September 11, 2012.
Rice was widely accused of deliberately misleading the public after she said only days later that, according to intelligence at the time, it had started with a spontaneous protest against a privately made anti-Islam film posted online.
Some Republican lawmakers accuse President Barack Obama of concealing evidence that Al Qaeda-linked jihadi groups were behind the attack and of failing to properly protect the outpost.
Asked in an exclusive interview Sunday with NBC's "Meet the Press" whether she had any regrets about her comments, made on the same program in September 2012, Rice said:
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"No, because what I said to you that morning and what I did every day since was to share the best information that we had at the time."
She added: "I commented that this was based on what we knew on that morning -- was provided to me and my colleagues, and indeed, to Congress by the intelligence community, and that's been well-validated in many different ways since."
Rice's comments were immediately dismissed by John McCain, an influential Republican senator.