The Department of Homeland Security said in a statement that an increased-level of security in and around public places and events may be experienced as officials take additional precautions.
"At this time, we have no information to indicate a specific credible threat involving other public venues in the country," it said.
The shooting was carried out by a lone gunman identified as Stephen Paddock, 64, from a 32nd floor hotel room on a nearby concert being attended by thousands of people.
"The Department is closely monitoring the situation and working with our federal, state and local partners in responding to and investigating this tragedy," the statement said.
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Reacting on the mass shooting incident, President Donald Trump said he and the First Lady Melania were praying for every American who has been hurt, wounded or has lost the loved ones in the "terrible" attack.
"We pray for the entire nation to find unity and peace. And we pray for the day when evil is banished, and the innocent are safe from hatred and from fear," he said.