It's a battle Pyongyang has tried before and won't easily win, especially since, beyond some stepped-up propaganda, it doesn't appear to have a lot of funding. But this time around, the effort does have one big thing going for it: the increasingly vocal support of North Korean women, virtually none of whom smoke.
The center, one of only 11 in all of North Korea, has something you almost never see in the North a no-smoking sign placed prominently above its entrance.
"I'm optimistic that we can get people to stop," she said. "Our goal is education."
The potential health benefit to the nation could be tremendous.
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Smoking is a social taboo for women and it's illegal for anyone under the age of 17.
North Korea has toyed with the idea of pushing harder to get smokers to kick the habit before Ri's humble anti-smoking center has been around since 2007. But it has stepped up its effort to at least provide more education of smoking's health risks since an anti-smoking decree was made by Kim in April.
The buzz didn't last long. He was pictured smoking on a visit to a children's camp in June.
North Korea joined the World Health Organization's Framework Convention on Tobacco Control in 2005 and dutifully holds events on World No Tobacco Day every year.