Adithan (63) was undergoing treatment in Hyderabad for the past one week for his kidney ailment and breathed his last on Tuesday, they said.
He is survived by wife and two daughters, they said, adding, the funeral will be held here tomorrow.
The musician is known for his numbers in films such as the super hit gangster flick 'Amaran', besides 'Seevalaperi Pandi,' in the early 90s.
He has scored music for many Telugu and Malayalam movies, the sources added.
Adithan also hosted a culinary show in a popular Tamil TV channel.