Novel eye test may help diagnose autism

A new test, which consists of measuring rapid eye movements, may help identify people with Autism spectrum disorders (ASD), scientists say.
The test may indicate deficits in cerebellum, an area of the brain that plays an important role in emotional and social development, researchers said.
"These findings build upon a growing field of research that show that eye movement could serve as a window into a part of the brain that plays a role in a number of neurological and development disorders, such as Autism," said John Foxe from University of Rochester Medical Center (URMC) in the US.
The rapid eye movements we make when we shift our attention from one object to another, known as saccades, are essential to navigating, understanding, and interacting with the world around us.

In healthy individuals, these saccades are rapid, precise, and accurate, redirecting the line of sight from one point of interest to another, researchers said.
The potential relevance of eye movement in individuals with Autism is the area of the brain that controls these actions, a densely-packed structure of neurons known as the cerebellum, they said.

Considered to play a role in motor control, the cerebellum is now known to be essential to emotion and cognition via its connections to the rest of the brain.
There is growing evidence that the structure of the cerebellum is altered in a sub-population of individuals with ASD.

Researchers tracked the eye movements of individuals with ASD. The participants were asked to track a visual target that appeared in different locations on the screen.
The experiment was designed in a manner that often caused the participant's focus to "overshoot" the intended target.
In healthy individuals, the brain would correctly adjust eye movements as the task is repeated, researchers said.
However, the eye movements of individuals with ASD continued to miss the target suggesting that the sensory motor controls in the cerebellum responsible for eye movement were impaired, they added.
The inability of the brain to adjust the size of eye movement may not only be a marker for cerebellum dysfunction, but it may also help explain the communication and social interaction deficits that many individuals with ASD experience.

"These finding suggest that assessing the ability of people to adapt saccade amplitudes is one way to determine whether this function of the cerebellum is altered in ASD," said Edward Freedman, associate professor at URMC.
"If these deficits do turn out to be a consistent finding in a sub-group of children with ASD, this raises the possibility that saccade adaptation measures may have utility as a method that will allow early detection of this disorder," Freeman said.
The research was published in the European Journal of Neuroscience.