Eight people were killed and 11 seriously injured in a Halloween afternoon attack that the mayor called "a particularly cowardly act of terror."
The driver identified by officials as an immigrant from Uzbekistan was in critical condition but expected to survive after a police officer shot him in the abdomen.
A roughly two-mile stretch of highway in downtown Manhattan was shut down for the investigation. Authorities also converged on a New Jersey apartment building and a van in a parking lot at a New Jersey Home Depot store.
Governor Andrew Cuomo said Wednesday on "CBS This Morning" the note made a reference to ISIS.
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Police and the FBI urged members of the public to give them any photos or video that could help. The attack echoed a strategy that the Islamic State group has been suggesting to its followers.
While police didn't specifically blame any group for the strike, President Donald Trump railed against the Islamic State and declared "enough!" and "NOT IN THE U.S.A.!"
The injured included students and staffers on a school bus that the driver rammed.
"This was an act of terror, and a particularly cowardly act of terror aimed at innocent civilians, aimed at people going about their lives who had no idea what was about to hit them," said Mayor Bill de Blasio, a Democrat.
Today, New Yorkers woke to a heavy police presence outside the World Trade Center and at other locations around the city. Runners and cyclists who use the popular bike path for their pre-dawn exercise were diverted away from the crime scene by officers stationed at barricades just north of where the rampage began, and a wide corridor of streets have been blocked.
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