"We're going to have to keep mobilising the world to meet shared challenges. And that includes strengthening international rules and norms that undergird peace and security," Obama said in his address to the Chief of Missions Conference at the State Department.
"We're going to have to continue to ensure that Iran fully meets its commitments under the nuclear deal; to make sure that we're enforcing effective sanctions on North Korea; that, at our upcoming summit here in Washington, we're continuing to increase nuclear security," he said.
"That's how we build a global coalition to deal with Iran -- strong sanctions plus diplomacy. And under the nuclear deal, Iran will not get its hands on a nuclear weapon," he asserted.
"That's how we work with countries like China and India and nearly 200 nations to reach the Paris agreement, the most ambitious global agreement ever to fight climate change," said the US President.
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"First and foremost, we've got to continue to keep our nation safe, especially from the threat of terrorism," he said.
"We're going to have to continue to strengthen our global coalition against ISIL, whether it's the air campaign, support for local partners, cutting off ISIL financing, preventing the flow of foreign terrorist fighters, working with partners to counter ISIL's bankrupt, nihilistic ideology," the US President said.
In the Asia Pacific, he said, the US would have to move ahead with its re-balance, strengthening alliances, partnering with ASEAN, supporting the transition in Myanmar, moving ahead with TPP and ensuring security and stability in places like the South China Sea.