"We have to be very pragmatic. And President Obama has been exceedingly pragmatic about our dealings with Russia. There are areas where we can cooperate with them. There are areas where we disagree bitterly with them," National Security Advisor Susan Rice told the NBC.
The US, she argued, has been able to reach a new and very important arm control agreement with the Russians -- the New START Treaty, she noted.
"On the other hand, we differ bitterly over issues of human rights. We differ over Syria. We differ over their treatment of LGBT persons, and we differ over a number of issues.
And the fact of the matter is, we should cooperate where we can. Where we can't agree and where we don't agree, we should be very plain about that and stand up for our interests, which we do," she said in response to a question.
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Rice said she views the US as the leading and most important global power because of the power of its economy, the power of values, the power of its military.
"We are and will remain the most important country in the world. And without our leadership, which we exercise every day actively from Africa to the Middle East to Asia, the world would not be nearly as stable and as prosperous as it is."
"As difficult and fraught as that is, we're making progress -- because of the US' leadership, we have the prospect of resolving the Iranian nuclear programme through diplomacy. We don't know that it will succeed, but we're closer to that goal than we have ever been," Rice said.