However, the highly anticipated trip threatens to be overshadowed by the deteriorating health of beloved former South African President Nelson Mandela.
Air Force One touched down in the Senegalese capital of Dakar yesterday evening. The president, who is traveling with first lady Michelle Obama and daughters Malia and Sasha, is also scheduled to visit South Africa and Tanzania.
The president is expected to be greeted warmly during his trip, despite the underlying sense of disappointment. American flags dotted the roadways as Obama's motorcade sped through this coastal city, and signs welcoming Obama and bearing his picture hung on homes and businesses.
"Africans were very excited when President Obama was elected and they expected deeper engagement than in the past, both in regard to policy and also in terms of actual visits to the continent, given the president's African heritage," said Mwangi Kimenyi, an Africa analyst at the Washington-based Brookings Institution.
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"Africans have been gradually disappointed, especially when they look at the focus on Africa by previous presidents, in particular President Clinton and President George W. Bush, who did quite a bit there."
The White House defended the purpose of the trip despite its low policy expectations.
"Presidential trips to regions of the world like Africa bring enormous benefits in terms of our relationship with the countries visited and the countries in the region," spokesman Jay Carney told reporters traveling with Obama on Air Force One.