He'll spend three days in Vietnam, with stops in Hanoi and Ho Chi Minh City, formerly Saigon, for meetings with top leaders, a speech on US-Vietnam relations, visits to cultural treasures and sessions with civic leaders and entrepreneurs.
From Vietnam, he heads to Japan for a summit of the Group of Seven industrialized nations and a historic visit to Hiroshima.
Along the way, Obama will make a big push for the 12-nation trans-Pacific trade agreement, which includes the US, Vietnam and Japan. The deal is stalled in Congress, but Obama hopes it will one day increase trans-Pacific trade and make it easier for US workers and companies to compete in Asia.
A key sticking point during Obama's stay in Vietnam will be human rights. Five Republican senators sent the president a letter yesterday labeling Vietnam "one of the most repressive regimes in the world" and urging Obama to press Vietnamese leaders to do more to respect freedom of religion and expression and other human rights.
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The letter was signed by Sens Marco Rubio of Florida, John Boozman of Arkansas, John Cornyn of Texas, James Lankford of Oklahoma and Bill Cassidy of Louisiana.
The Catholic archdiocese of the central city of Hue reported on its webpage that it welcomed the return yesterday of the Rev Nguyen Van Ly from prison. Ly, 70, has served several long terms in prison or under house arrest for promoting political and religious freedoms in the communist nation.
Obama's final year in office is heavy with foreign travel as he conducts what amounts to a long, global farewell tour.