This would be the first bilateral meeting between the two leaders after both returned to office.
"They clearly have a very broad agenda to discuss. That will include the situation in Syria. That will include Afghanistan, where Russia has cooperated with us in securing both our transit routes for our troops and also promoting stability in the region," Deputy National Security Advisor Ben Rhodes told reporters at a White House news conference.
He said it is in Russia's interest to join international community in putting presser on the Assad regime in Syria.
"It is (in) Russia's interest to join us in applying pressure on Bashar al-Assad to come to the table in a way that relinquishes his power and his standing in Syria, because we don't see any scenario where he restores his legitimacy to lead the country," he said.
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The meeting between Obama and Putin comes days after the US president's announcement to send military support to rebels fighting the Syrian government.
"I think the President will definitely be discussing the types of aid and assistance that we provide into Syria. In particular, the countries that work with us on that are our European allies, and the French and the British have been the most prominent in that regard. So I think he'll be discussing it broadly," Rhodes said.
Rhodes said the US continues to discuss with the Russians whether there is a way to bring together elements of the regime and the opposition to achieve a political settlement.
"Frankly, the type of relationship we have with the Russians is such that even as we have disagreements, and even strong disagreements in some areas, we want to work together on issues where we do have convergence of interest," he said.