"The bigger concern at this point is not just hurricane force winds, but storm surge," Obama said in the Oval Office, stressing the threat to the Jacksonville area in northern Florida, up as far as Georgia.
"I emphasise this is still a really dangerous hurricane," Obama said after receiving a briefing from aides including Craig Fugate, administrator of the Federal Emergency Management Agency.
The Category 3 storm has so far caused limited damage in the United States, but has killed at least 400 people in Haiti.
"Pay attention to what your local officials are telling you," he said. "We can always replace property. We cannot replace lives."
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He recalled the lessons of Hurricane Sandy, which slammed into New Jersey and New York City in 2012, leaving 200 dead and causing tens of billions of dollars in damages.
"Initially people thought 'this doesn't look as bad as we thought,' and then suddenly you get a massive storm surge and a lot of people were severely affected."
Today he warned that "the potential for storm surge, flooding, loss of life and severe property damage continues to exist."
Obama said he was also tracking the damage done in Haiti, "one of the poorest countries in the world.