Welcoming Sharif for his second bilateral meeting with him, Obama said the two sides are "looking forward to using this opportunity to deepen this relationship between the United States and Pakistan".
"Obviously, the United States and Pakistan have a longstanding relationship. We work and cooperate on a whole host of issues - not just on security matters, but also on economic and scientific and educational affairs," he told reporters as he welcomed Sharif in his Oval Office.
"The Pakistan-America relations stand over 70 years, and it is my endeavour to further strengthen and solidify this relationship."
The meeting between the two leaders comes a week after Obama said he will not pull out American troops from Afghanistan before he demits office next year.
More From This Section
"The visit will highlight the enduring nature of the US- Pakistan relationship and provide an opportunity to strengthen our cooperation on issues of mutual interest, including economic growth, trade and investment, clean energy, global health, climate change, nuclear security, counter-terrorism and regional stability," the White House said in a statement.
Ahead of the meeting, Pakistani officials said that Sharif would raise the Kashmir issue with Obama.
"During the Prime Minister's visit, we will talk about the tension with India on the Line of Control," Foreign Secretary Aizaz Ahmad Chaudhry said on Monday.
"It is the responsibility of the US and the international community to help resolve the problem of Kashmir, which was the main issue with India," he added.