The three Democratic Party champions, along with First Lady Michelle Obama, will lay a wreath close to the eternal flame that marks the resting place of the 35th US president at Arlington National Cemetery outside Washington.
The poignant moment of remembrance will come two days before the November 22 half century anniversary of Kennedy being gunned down in an open top limousine in Dallas, in a crime which traumatised the world.
The White House said Obama would also give a speech on Wednesday evening honouring Kennedy's legacy of service at a dinner honoring awardees of the Presidential Medal of Freedom at the Smithsonian Institution in Washington.
Former president Clinton, former Washington Post editor and Kennedy confidant Ben Bradlee and talk show host Oprah Winfrey are among those getting medals this year.