"This bilateral meeting will present an opportunity to advance US-China cooperation on a range of issues of mutual interest, while also enabling President Obama and President Xi to address areas of disagreement constructively," White House Press Secretary Josh Earnest said.
Heads of states from over 40 countries, including Prime Minister Narendra Modi, will attend the two-day Nuclear Security Summit in Washington on March 31 and April 1.
The meeting is regarded significant as it provides an opportunity for the two leaders to discuss bilateral tensions over the South China Sea, where the US is challenging China's claims by sending its naval ships and aircraft.
Li said Xi will also meet with other state leaders on the sidelines of the summit to exchange views on bilateral relations as well as international and regional issues of common concern.