The state government which has already allocated Rs 95 crore for the purpose, will provide the entire fund from its own resources.
Chief Secretary A P Padhi said he has asked the departments of Health and Family Welfare and Woman and Child development to integrate various initiatives for ensuring the scheme's success.
Though the official data shows that the IMR in Odisha is on a declining trend, the recent deaths of 19 children allegedly due to malnutrition at Nagada village in Jajpur district, has forced the government to take special care of children and pregnant mothers.
At least 15 of the 30 districts of the state have been identified as prone to infant and mother death cases.
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The districts are Bolangir, Boudh, Deogarh, Gajapati, Kalahandi, Kandhamal, Keonjhar, Koraput, Malkangiri, Sonepur, Mayurbhanj, Nabarangpur, Nuapada, Rayagada and Sundergarh.
The scheme will be implemented in 161 backward and remote blocks of the 15 districts, said Health and Family Welfare Secretary Arati Ahuja.
An amount of Rs 5 crore to Rs 10 crore has been allocated keeping in view the requirement of each of the districts, they said.
Besides imparting training to the staff, the state government has formed 15 teams for proper implementation and evaluation of the scheme.