The strike occurred overnight Thursday into Friday, the officials told The Associated Press. It did not appear that a chemical weapons site was targeted, they said, and one official said the strike appeared to have hit a warehouse.
The U.S. Officials spoke on condition of anonymity because they were not authorized to discuss the matter publicly.
Israel has targeted weapons in the past that it believes are being delivered to the Lebanon-based militant group Hezbollah. Earlier this week, Hezbollah leader Sheikh Hassan Nasrallah said his group would assist Syrian President Bashar Assad if needed in the effort to put down a 2-year-old uprising.
"What we can say is that Israel is determined to prevent the transfer of chemical weapons or other game-changing weaponry by the Syrian regime to terrorists, specially to Hezbollah in Lebanon," Sagui said in an email to the AP.
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In 2007, Israeli jets bombed a suspected nuclear reactor site along the Euphrates River in northeastern Syria, an attack that embarrassed and jolted the Assad regime and led to a buildup of the Syrian air defense system. Russia provided the hardware for the defense systems upgrade and continues to be a reliable supplier of military equipment to the Assad regime.
The Israeli strike also follows days of renewed concerns that Syria might be using chemical weapons against opposition forces. Obama has characterized evidence of the use of chemical weapons as a "game-changer" that would have "enormous consequences."
While the U.S. Has been providing nonlethal aide to opposition forces in Syria, even stepping up that form of support in recent days, the Obama administration has resisted calls from some American lawmakers to arm the rebels or to work to establish a no-fly zone to aid the insurgency.