The 65-year-old actor will star in 'Aadupuliattam' to be directed by Kannan Thamarakulam.
The "Ardh Satya" actor will play the role of a mystic scientist, who carries out research on soul and incarnations.
According to the director no one in Indian cinema is as perfect as Om Puri to play the character, which demands a lot of depth and emotional intensity.
"Only very few actors in Indian cinema might have enacted the wide range of characters played by Om Puri. We hope that the character in Aadupuliattam will be a special one in his career," Kannan told PTI.
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The first schedule of the shooting of the movie will begin tomorrow in Thodupuzha.
Om Puri is expected to join the crew in the second schedule which will be shot in Palani in Tamil Nadu during January.
The movie, which revolves around a centuries-old myth and travels from the present to the past, will also have Jayaram, Jewel Marry and south Indian actress Ramya Krishnan in the cast and is expected to be released by mid 2016.