The car, driven by a doctor in his late fifties, first rammed into four motorcycles near Ashoka Pillar before colliding with two cars and two two-wheelers near Byrasandra Circle in Jayanagar area.
The car finally came to a stop after ramming into a 'katchcha' house nearby, destroying it, police said.
One person, identified as Rizwan, a two-wheeler rider died on the spot near Byrasandra Circle, while his wife sustained injuries and is undergoing treatment at a local hospital.
Locals, who caught hold of the driver, handed him over to police. They told police that the man was accompanied by a woman and two children in the car.
Police, who have arrested the driver of the car, said, he has been sent for a medical test.
CCTV footage of the incident that is being telecast by local channels shows a speeding car ramming into a motorcycle and two cars before proceeding further.