When Winfrey delivered a rousing speech at the Golden Globe Awards earlier this month it rekindled longstanding speculation over the billionaire's political ambitions -- and a possible run for the Oval Office.
Some Democrats -- still reeling from Hillary Clinton's shock loss to Donald Trump -- have embraced the idea of having their own celebrity candidate the next time around.
But in an interview with InStyle, carried out three weeks before the Globes and published in the fashion magazine's March issue, the 63-year-old downplayed the idea of a presidential run, saying: "That's not for me."
"And so it's not something that interests me. I don't have the DNA for it," she added.
More From This Section
It was unclear whether the enthusiastic response to her Globes speech -- after which anonymous friends of the chat show queen were reported as saying she was "actively thinking" about a 2020 run -- may have brought a change of heart.
Winfrey went on in the interview to voice optimism about the current political US political climate.
"I think what's exciting is this moment in our political history, in our social engagement," she said.
Winfrey, the first black woman to own a television network, also reflected on the wave of sexual misconduct allegations gripping the worlds of entertainment, media and politics -- the core of her Globes speech, in which she heralded a "new day" following the watershed.
"It has seared into the consciousness a level of awareness that was not there before," she told InStyle.