Winfrey, 60, posted a picture of herself with Lohan, 28, at backstage on Instagram, reported E! Online.
"Lindsay Lohan backstage at her new play in London. SpeedthePlow," Oprah captioned the photograph.
Lohan wrote, "So thrilled to have Oprah and Lupita N'yongo in the audience tonight. I'm a lucky girl! My fairy godmother."
Lohan stars alongside Richard Schiff in 'Speed-the-Plow', which is a satirical dissection of the American movie business and features three different acts.