The 59-year-old star gave birth to a baby boy prematurely when she was 14 but the baby died after a few weeks, reported Contactmusic.
"If I had kids, my kids would hate me. They would have ended up on the equivalent of the Oprah show talking about me; because something (in my life) would have had to suffer and it would've probably been them," said Winfrey.
The 'Butler' actress was very ambitious compared to her childhood best friend Gayle King when they were younger.