Winfrey, 59, is trying to raise funds for Oprah Winfrey Leadership Academy Foundation College Fund that helps girls, who graduate from her school in Africa, to pay their university fees, reported Contactmusic.
The earnings are planned to made by selling items from her homes from all over the United States, including residences in Chicago, California, Indiana and Hawaii.
The chat show host is also auctioning off numerous home furnishings such as glamorous chandeliers, a marble bathtub, and a side table which is thought to be from the late 18th Century or early 19th Century.