Winfrey, 58, forged a big bond with the Kardashian family during her recent sit-down interview on OWN, reported Us magazine.
"She and Khloe [Kardashian Odom] especially hit it off. Khloe had her dying laughing. It meant so much because she loves Oprah," said a source.
The talk show queen was so enamored with the clan that she agreed to appear on "Keeping Up With the Kardashians", said the source.
Winfrey's representative confirmed that she will appear on the E! show.
During her interview with Kim, Winfrey was floored by the reality star's strength after her public split with Kris Humphries after 72 days of marriage.
"I've obviously made plenty of mistakes in my lifetime, but I'm not the type to sit and beat myself up over it. If a real lesson was learned, I'm so okay with having experienced that," Kim said.
"That is so perfect I could weep," replied Winfrey.