"Liftoff, on the shoulders of Atlas," NASA spokesman Mike Curie said as the unmanned spacecraft blasted off from Cape Canaveral, Florida atop an Atlas V rocket at 4:44 pm (2144 GMT) yesterday.
The launch marks Orbital's fourth scheduled mission to the orbiting outpost, as part of a USD 1.9 billion contract with NASA to deliver necessities to the astronauts living in space.
The spacecraft is carrying the most cargo ever packed onto a barrel-shaped Cygnus, with some 7,300 pounds (3,300 kilograms) of gear, including science experiments, ready-made food, a jet pack for spacewalking astronauts and even a satellite made by elementary school students.
It was followed eight months later by a SpaceX rocket explosion, and the consecutive accidents effectively shut off the flow of US supplies to astronauts in orbit.