"They have forgotten all their values," Pamuk told the Hurriyet newspaper in an interview, referring to the EU, adding that the fight against the Islamic State group and the migrant crisis had "tied Europe's hands".
Brussels reached an agreement with EU hopeful Turkey in November to encourage Ankara to keep refugees inside its territory, after a mass influx of migrants crossed into the EU last year, stoking tensions in several member states.
Pamuk criticised the 28-nation bloc for ignoring Turkey's recent record in freedom of expression under the rule of President Recep Tayyip Erdogan's Justice and Development Party (AKP).
"They are looking to us as they looked to Saudi Arabia once upon a time: If (Turkey) is doing what we want, we don't care what they do at home."
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Pamuk lamented recent developments in Turkey, including the detention of leading opposition journalists Can Dundar and Erdem Gul on charges of revealing classified information.
"I am a person who says 'let's talk about literature only' but it is no longer possible," Pamuk said.
"You cannot sit and write your novel when Can Dundar is in jail."
An advocate of Turkish membership of the EU, Pamuk said: "In democratic countries, people do not have to repeat like a parrot the opinions of the (party) that won the last election."
The author, who was awarded the Nobel Prize for Literature in 2006, has just completed a new novel "The Red-Haired Woman," which will be released in Istanbul on Tuesday.