The Phenom 300 jet which was arriving from Italy crashed during an attempt to land at Blackbushe Airport in Hampshire, some 65 kilometres from here, killing all four persons on board including the pilot yesterday though it was not clear how many of them were Osama's relatives.
The Saudi Arabia-registered plane had ploughed into a car auction site and burst into flames.
Saudi ambassador Prince Mohammed bin Nawaf Al Saud offered condolences on the embassy's official Twitter handle to the bin Laden family, a prominent Saudi clan with vast business interests but did not identify the victims.
According to reports in the Arab media, the dead included stepmother Rajaa Hashim and sister Sana of Osama, who was killed in 2011 by US Navy SEALS in Pakistan.
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The 9/11 attack mastermind's brother-in-law - Sana's husband - Zuhair Hashim is also believed to be among the dead, 'The Daily Telegraph' reported.
The aircraft, which was understood to be flying from Milan-Malpensa Airport in Italy, came down after overshooting the runway and clipping a fence. The Embraer jet then flipped over and landed on a number of cars in an adjacent auction site, sparking a huge blaze.
Around 20 cars were completely destroyed.
An eyewitness to yesterday's crash said the jet exploded on impact at the British Car Auctions site, that operates an auction site and warehouse at the Hampshire airfield.
The plane was owned by Salem Aviation, a company which is part of the bin Laden conglomerate based in Jeddah.
If the deaths of members of the bin Laden clan are confirmed, it would be the third time the family had fallen victim to a plane crash.
On September 3 1967, Osama's father Mohammed bin Laden was killed when his Beechcraft 18 crashed on a landing strip near Usran in Saudi Arabia.