Paes and Hingis, winners of three Grand Slam titles last season, won 6-4 6-4 against the German-Colombian team.
After breaking each other once, the two pairs were level 2-2 when Paes and Hingis broke again and held their own to nose ahead 4-2.
That lead stayed with them as the two pairs managed to hold serve after that and Paes and Hingis served out the opening set comfortably in the 10th game.
In the second set, Paes and Hingis again broke early -- in the third game -- for a lead. They staved off two break chances in the eighth game to keep the advantage with them.
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They next face winners of the other first round match between the fourth-seeded pair of Yaroslava Shvedova and Florin Mergea and Lucie Hradecka and Marcin Matkowski.
Later in the day, Sania Mirza will also open her mixed doubles campaign with partner Ivan Dodig. The second seeds face local pair of Mathilde Johansson and Tristan Lamasine.
Another Indian playing today is Purav Raja, who with Ivo Karlovic, face the ninth seeded Lukasz Kubot and Alexander Peya.