While Paes and Raja suffered a straight-set defeat at the hands of Juan Sebastian Cabal and Robert Farah of Colombia in the men's doubles pre-quarterfinals, Bopanna and Babos easily edged past Australian pair of Andrew Whittington and Ellen Perez in the mixed doubles first round.
The unseeded Paes and Raja were beaten 1-6 2-6 by their 11th seeded opponents in a contest that lasted one hour and nine minutes at the Melbourne Park here.
The Colombian duo broke the Indians twice in both the sets to easily grab the match and make it to the quarterfinals.
The Indian pair had shocked the formidable fifth seeds Bruno Soares and Jamie Murray in the second round but their game were not up to the mark today.
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Paes and Raja, who won two Challenger level titles to close the 2017 season, were playing in their second Grand Slam together.
Paes has not featured in the quarterfinals of a Grand Slam event for more than a year. The last time 44-year-old Paes played a quarterfinal at a Grand Slam was in 2016 at French Open where he and Marcin Matkowski had lost to Mike and Bob Bryan.
Meanwhile, Bopanna and Babos dispatched the unseeded Australian pairing of Whittington and Perez 6-2 6-4 in a first round mixed doubles match lasted less than an hour.
The fifth seeded Indo-Hungarian pair looked dominant from the start breaking Whittington's serve in the very first game.
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