Abbasi's address to the UNGA - slated for September 21 - will be his debut into the highest international diplomacy after being sworn in as the prime minister last month.
Pakistan's Ambassador to the UN Maleeha Lodhi has said that the prime minister will highlight the Kashmir issue and other issues of concern to Pakistan.
India's Permanent Representative to the UN Syed Akbaruddin last week said Pakistan's decision to raise the Kashmir issue at the UN, which has not been discussed at the world body for decades, is like 'Miyan ki daud masjid tak', referring to a popular Urdu proverb meaning some people think within a limited focus and are unable to think beyond that.
Abbasi's visit comes amidst tensions in the ties between Pakistan and the US after President Donald Trump last month hit out at Islamabad for providing safe havens to "agents of chaos" that kill Americans in Afghanistan and warned Islamabad that it has "much to lose" by harbouring terrorists.
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He would meet US Vice President Mike Pence here at the UN headquarters later today, the White House said.
Ahead of Abbasi's meeting with Pence, Pakistan's Foreign Secretary Tehmina Janjua yesterday met US Under Secretary of State Tom Shannon.
"She stressed that intra-Afghan dialogue is vital for bringing lasting peace to the country and the region. Pakistan would continue to play a facilitating role for a peaceful Afghanistan," the statement said.
Abbasi is scheduled to hold bilateral meetings with a number of world leaders including Jordan, Turkey, Afghanistan, Sri Lanka, Iran, the United Kingdom and Nepal.
In addition to meeting UN Secretary-General Antonio Guterres, he is also scheduled to address the Council on Foreign Relations.