Anwarullah Khan Afridi, a student of intermediate at Army Public School Karachi, said he was excited at meeting Sharif who was in the city on an official visit.
Afridi shared his experience of a foreign visit with the prime minister, particularly his meeting with Pakistani education activist and Nobel laureate Malala Yousafzai.
Sharif's office said he enquired about Afridi's health and enjoyed the cheerful moments filled with motivation and appreciation. He asked Afridi about his family and hobbies.
"Anwarullah also shared his feelings with the Prime Minister," an official statement said.
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While praying for his recovery and good health, Sharif told Afridi that he was a source of inspiration and courage.
He also directed officials for immediate compliance of Anwarullah's desire to meet Punjab province's Chief Minister Shahbaz Sharif.
Sharif said that granting wishes of such children change their lives a great deal.
"Make a wish work compels us to exceed the expectations of every wish kid and drives us to ensure that our attention has a far reaching impact," he said.