Faisal Raza Abidi, an outspoken former anti-Taliban Shiite lawmaker from Pakistan's liberal People's Party, is among those facing questioning, said counter-terrorism police officer Junaid Sheikh.
The police and Pakistan's paramilitary forces have raided both Sunni and Shiite religious seminaries over the last two days, detaining an unspecified number of people, Sheikh said.
Sunni and Shiite activists have rallied in Karachi, protesting against the raids. One of the rallies by the Shiites blocked a highway for eight hours, which the police dispersed with tear gas.
Pakistan's Sunni militants, many affiliated with the Taliban and al-Qaeda, have long targeted minority Shiites, considering them to be heretics.
The police suspect some of Karachi's recent sectarian killings of Sunnis could be the work of Shiite militants.
Pakistan has been fighting the Islamic militants and their sectarian allies for over a decade; the militants have a strong presence in urban areas and ties with Taliban and al-Qaida linked foreign militants in tribal regions along Afghan border.
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