The drive in Bajaur Agency began just days after authorities said the number of new polio cases reported in Pakistan this year had touched 62, four times higher than the whole of last year.
Women workers will not participate in the campaign because of security reasons, officials said today.
"It has been decided in a meeting that the female staff will not take part in the current drive due to security concerns," said Zakir Hussain, the main surgeon of Bajaur Agency.
Durry said 85 per cent of new polio cases are emerging in Taliban strongholds like North Waziristan, Khyber Agency and other tribal areas.
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Pakistan is one of only three countries where the crippling disease continues to be endemic.
The Taliban denounced vaccines as a "Western plot" to sterilise Muslims and imposed a ban on vaccinations in North Waziristan in June 2012, stipulating the restriction would last until US drone attacks cease.
"It is a fact that polio becomes a national issue and the government is struggling to purge this disease which is not possible without the cooperation of the community," Bajaur Agency Political Agent Syed Abdul Jabar Shah said.
The inaugural ceremony of the latest drive was held in the agency headquarters hospital yesterday and was attended by senior officials of the health department, WHO, tribal elders and religious scholars.
Shah said that administration is adopting all possible means to defeat polio in the agency bordering Afghanistan.
Officials said 628 health teams would vaccinate 223,680 children in the agency.