White House hopeful Donald Trump mentioned Pakistan in a speech this week in New Hampshire as he doubled down on anti-immigration threats in the wake of the bloody rampage in Orlando.
Trump cited an attack in California last November, when a Pakistani woman and her US-born husband were praised by IS as "soldiers" of the caliphate after killing 14 people.
Other murky links between Pakistan and IS attacks have also emerged.
In April, Austrian prosecutors said they are investigating a Pakistani held in connection with last November's deadly assault on Paris, also claimed by IS.
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Washington earlier this year designated an IS affiliate -- the "Khorsan Province" -- as a Afghanistan- and Pakistan-based terrorist organisation.
But Islamabad officially denies IS has a formal presence in the country.
Analysts say that while the group's ultra-violent ideology has seen some success as a recruitment tool, IS is still scrabbling for purchase in Pakistan largely due to competition from well established extremist groups already there.
"I don't see it as having the potential to make large-scale territorial gains and existentially threatening Pakistan as a nation," said Aymenn Jawad Al-Tamimi, a research fellow at the US-based Middle East Forum.
"I am also somewhat sceptical of the potential to supplant al-Qaeda and the Taliban," he wrote in an email to AFP.
Attacks claimed by IS in Pakistan are rare, the most significant being a 2015 gun assault on a bus in Karachi that killed 44 people.
"Educated, motivated and unemployed youth are an IS recruitment base in Pakistan. We have busted several recruitment cells here," a senior security official told AFP on condition of anonymity.