Pakistan, fourth in the Twenty20 rankings, are also aiming to topple Sri Lanka from the top of the standings by winning both matches, the second of which takes place on Friday.
"Sri Lanka are a top side so this is in itself a motivation to beat the number one side and if we win both it will lift us to the top of the world," Pakistan captain Mohammad Hafeez said.
If the series is a 1-1 draw the teams will maintain their current rankings while a 2-0 loss would push Hafeez's team down to fifth.
They also overcame tough resistance from minnows Afghanistan by six wickets in a last ball thriller in Sharjah on Sunday -- the first Twenty20 between the two countries.
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Pakistan will be at full strength and boosted by the return of magician off-spinner Saeed Ajmal, who skipped Sunday's game to rest back home.
"We leaked quite a few runs against Afghanistan so we will have to be at our best to beat Sri Lanka and Ajmal's return will help that," said Hafeez, who was man of the match against Afghanistan for his 42 not out.
Last month they beat New Zealand 1-0 with the other match abandoned because of inclement weather.
"The advantage Pakistan's got is that they have played a lot of international cricket in the last six-eight months whereas unfortunately we haven't played nearly as much because of weather and various other things," said coach Graham Ford.