In a statement today, Medecins Sans Frontieres, also known as Doctors Without Borders, said the government move ends 14 years of operation in the Kurram tribal region.
Kurram has witnessed scores of militant attacks against minority Shiites Muslims in recent years.
Doctors Without Borders was providing medical facilities in collaboration with two government hospitals.
No government spokesman was available for comment.
Pakistan in recent years has shut the offices of some non-government organisations for working without a No Objection Certificate from the Ministry of Interior, which monitors activities of foreign-funded organisations in tribal regions for security reasons.
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