"A terrorist, who arrived armed with a knife, tried to stab a security guard at the site. In response, the terrorist was shot by the security force at the scene and killed," a police statement said.
Police said the alleged attacker arrived from the Palestinian side of the Al-Jalama checkpoint between the northern West Bank and Israel.
As at other such checkpoints, private security guards operate alongside troops.
Eight Israelis have been killed in attacks. One Israeli Jew and one Eritrean were killed after being mistaken for attackers.
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Earlier today, an Israeli told police he had fought off an attempted knife attack near the Old City in annexed east Jerusalem. The alleged assailant fled.
There has been a wave of lone-wolf knife attacks, shootings and car-rammings against Israeli soldiers, police or civilians since October 1 as tensions have soared over the status of Jerusalem's Al-Aqsa mosque compound, a site that is sacred to both Muslims and Jews.