Pallikal dispatched second seed and last year's runners-up Heba El Torky 11-4 11-9 11-8 in yesterday's final of the USD 15,000 event.
The world no.13 from India had also won the title here in 2013 before compatriot Joshana Chinappa lifted the trophy last year.
Pallikal had reached the final -- the 15th of her career on the WSA World Tour -- after beating Donna Urquhart, the fourth seed from Australia making her Tour return after a six-month foot injury break.
"It is a great win considering it is my first tournament of the year. All the matches were tough," Pallikal told PTI today.
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Pallikal usually trains abroad with former five-time world champion Sarah Fitz-Gerald in Melbourne but she recently spent some time with renowned Egyptian coach Amir Wagih in Washington DC before beginning her US leg of the season.
"Last year turned out to be the best year of my career with win in Glasgow but it is now back to the grind of professional squash. I consistently need to beat the top players and get back into the top-10," she added.