The actress-model will grace the front of the magazine for a record 13th time since 1989. This also marks her 15th Playboy pictorial to date, reported Variety.
The publication announced in October that it will no longer showcase nude women, ending a 60-plus-year tradition. Playboy featured Marilyn Monroe on its debut cover in 1953.
"I got a call from (Hugh Hefner's) attorney who said, 'We don't want anybody else. There's nobody else, could you do the last cover of Playboy?'" Anderson said.
The 48-year-old mother of two said she was initially hesitant to pose nude again because both of her sons have been teased in the past for her work. But 19-year-old Brandon and 17-year-old Dylan both ended up encouraging her to do the shoot.
"'We're older, we're not embarrassed anymore of you. You know, we think you're great.'"
The January/February 2016 edition of Playboy, which includes Anderson's 12-page pictorial and features an interview conducted by James Franco, hits newsstands on December 11.