Karnataka now have a 60-run lead with six wickets in hand after they bowled out Odisha for 228.
Openers Robin Uthappa (33) and Mayank Aggarwal (23) got out after getting set but Pandey in company of the dogged Lokesh Rahul (67, 144 balls, 11x4) added 114 runs for the third wicket.
Pandey's unbeaten knock came off 198 balls with 13 fours and two sixes. Rahul was finally dismissed when he edged one to wicketkeeper Subhrajit Sahoo off Biplab Samantray's bowling.
At stumps, CM Gautham (11 batting) was giving Pandey company as the visitors looked to build on this solid foundation.
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For Odisha, Basant Mohanty, Deepak Behera and Samantray got a wicket apiece.
Brief Scores: Odisha 1st Innings 228.
Karnataka 1st Innings 288/4(Manish Pandey 108 batting, KL Rahul 67, Kunal Kapoor 25). Karnataka are 60 runs ahead.