Parrikar, 62, was flown to Mumbai and admitted at Lilavati Hospital last evening for a check-up.
"The chief minister will fly to the USA tomorrow by an early morning flight at 1.30 AM for further treatment," state BJP general secretary Sadanand Tanawade said.
A state government official too confirmed the development.
Parrikar was admitted to Lilavati Hospital in Mumbai on February 15 and discharged on February 22. On the same day he returned to Goa and presented the Budget in the assembly, but the session was truncated to only four days owing to his illness.
Before leaving for Mumbai yesterday, Parrikar held a series of meetings, including one with senior state ministers.
A three-member Cabinet Advisory Committee of Sudin Dhavalikar (MGP), Francis D'Souza (BJP) and Vijai Sardesai (Goa Forward Party) was also formed to advise the administration in his absence.