No casualties were reported. All passengers have been evacuated, state-run Xinhua news agency reported.
One compartment of the train en route from Chengdu, capital of southwest China's Sichuan Province, to Changsha, capital of central China's Hunan Province, ran off the line at about 7:10 a.M. Local time, it said.
Railway authorities have launched an emergency response to the accident.
Cause of the accident is being investigated.